RecruitingNot Applicable

Non-invasive Detection of Acute Cell-mediated Graft Rejection in Pediatric Heart Transplant Recipients

Italy30 participantsStarted 2023-12-12

Plain-language summary

Acute cardiac rejection is currently diagnosed by endomyocardial biopsy (EMB), but multiparametric cardiac magnetic resonance (CMR) may be a non-invasive alternative by its capacity for myocardial structure and function characterization. Our primary aim was to determine the utility of multiparametric CMR in identifying acute graft rejection in paediatric heart transplant recipients. The second aim was to compare textural features of parametric maps in cases of rejection versus those without rejection.

Who can participate

Age range18 Years

SexALL

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Inclusion Criteria: * children and young adults (transplanted when they were ≤ 18 years) who undergo an EMB for routine surveillance without contraindications to contrast-enhanced CMR Exclusion Criteria: * We also don't recruit recipients who were \< 3 months post-heart transplantation to reduce the possibility of confounding from ischemia-reperfusion injury that occurs with the heart transplant procedure

What they're measuring

To determine the utility of multiparametric CMR in identifying acute graft rejection in paediatric heart transplant recipients

Timeframe: 1 year

Trial details

NCT IDNCT06795958

SponsorIRCCS Azienda Ospedaliero-Universitaria di Bologna

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2029-06-30

Contact for this trial

Valentina Gesuete, MD

0390512149096 valentina.gesuete@aosp.bo.it

View on ClinicalTrials.gov More Pediatric Heart Transplant trials