Phenylketonuria is an inborn error of phenylalanine metabolism. Although the phenylalanine-restricted diet is recognized as the mainstay of therapy, little is known about the impact of protein substitutes on the metabolism of patients with phenylketonuria. Therefore, the aim of this project is to study the impact of acute ingestion of casein glycomacropeptide supplemented with amino acids (cCGMP-AAs) alone or in combination with two different meals on amino acid absorption kinetics, glycaemic and insulinemic response, and on acute markers of appetite control. The main findings of this project will bring new insights into the dietary management of these patients, which may lead to improvements in protein substitutes formulations.
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Changes in the iAUC (mmol/L*min) for total amino acids
Timeframe: 180 minutes
Changes in the iAUC (pmol/L*min) for glucagon-like peptide-1 (GLP-1)
Timeframe: 180 minutes
Changes in the iAUC (pmol/L*min) for Cholecystokinin (CCK)
Timeframe: 180 minutes
Changes in the iAUC (pmol/L*min) for peptide YY (PYY)
Timeframe: 180 minutes
Changes in the iAUC (pmol/L*min) for Gastric inhibitory polypeptide (GIP)
Timeframe: 180 minutes