Effects of Ventilator Hyperinflation Versus Vibrocompression in Mechanically Ventilated Patients (NCT06791798) | Clinical Trial Compass
RecruitingNot Applicable
Effects of Ventilator Hyperinflation Versus Vibrocompression in Mechanically Ventilated Patients
Egypt81 participantsStarted 2025-02-01
Plain-language summary
The aim of the current study is to compare the effects of ventilator hyperinflation and vibrocompression on lung compliance in mechanically ventilated patients.
Who can participate
Age range
35 Years – 55 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Eighty-one mechanically ventilated patients more than 48 hours up to 7 days
* Their ages range from 35 to 55 years old.
* Medical stability (mean arterial pressure \> 60 \< 110, systolic blood pressure \> 80, diastolic blood pressure \> 60, fraction of inspired oxygen \< 60, positive end expiratory pressure (PEEP) \<10)
Exclusion Criteria:
Patients will be excluded if they have the following conditions or diseases:
* Unstable hemodynamics
* Fraction of inspired oxygen (FiO2) ≥ 0.6
* PEEP ≥ 10 cmH2O
* undrained pneumothorax and hemothorax or subcutaneous emphysema
* Pulmonary pathology (e.g., acute respiratory distress syndrome, exacerbation of chronic obstructive pulmonary disease, and acute pulmonary edema)
* Unstable neurological problems (raised intracranial pressure).
* Lung Cancer
* Recent/unhealed rib fracture
* Any disease obstructs our study.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Static Compliance
Timeframe: Before, after treatment at Day 1 and Day 4
2
Airway Resistance
Timeframe: Before, after treatment at Day 1 and Day 4
3
Sputum Volume in ml
Timeframe: Immediately after treatment at Day 1 and Day 4
4
Peak Expiratory Flow and Peak Inspiratory Flow
Timeframe: Before, after treatment at Day 1 and Day 4