RecruitingNot Applicable

Assessment of Pro-Resolution Mediator Levels in Periodontitis Stage III and IV Before and After Periodontal Therapy

Egypt22 participantsStarted 2022-10-15

Plain-language summary

This study aims to assess Pro-Resolution Mediator levels during non-surgical periodontal therapy in individuals with Stage III and IV periodontitis, comparing them to healthy subjects. Periodontitis, a chronic inflammatory condition affecting tooth-supporting tissues, can lead to tooth loss and systemic complications. Understanding the role of pro-resolving lipid mediators in inflammation resolution may offer insights into therapeutic benefits associated with these mediators.

Who can participate

Age range18 Years – 80 Years

SexALL

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Inclusion criteria

✓. Adult patients above 18 years old.
✓. Interdental CAL at site of greatest loss ≥5 mm or extending to middle third of the root.
✓. Interdental CAL at site of greatest loss ≥8 mm or extending to apical third of the root.
✓. Probing depth ≥6 mm.
✓. Vertical bone loss ≥3 mm.
✓. Tooth loss due to periodontitis of ≤4 teeth. (Periodontitis Stage III)
✓. Tooth loss due to periodontitis of ≥5 teeth. (Periodontitis Stage IV)
✓. Furcation involvement Class II or III Moderate ridge defect.

Exclusion criteria

✕. Systemically healthy patients.
✕. Patients with an age range between 16 to 80 years.
✕. Patients have a minimum of 20 teeth.
✕. Less than 10% bleeding sites with probing depths ≤3 mm.
✕. absence of erythema, oedema.

What they're measuring

Change in level of GCF lipoxin A4

Timeframe: preoperative, one day, one month and 3 months postoperative

Trial details

NCT IDNCT06789458

SponsorCairo University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-10-14

Contact for this trial

Husam Ghazi Alharbi, Master Degree

+201222284055 husam.ghazi@dentistry.cu.edu.eg

View on ClinicalTrials.gov More Peridontal Disease trials