The goal of this observational study is to study the health status of infertile couples and their offspring using assisted reproductive technologies. The main questions it aims to answer are: 1. On the basis of the assisted reproduction birth cohort and related research established by the team in the early stage, further expand the construction of the "tracking cohort of familial health and development using assisted reproduction", combine emerging technologies such as cross-database linking and integration, multi-omics sequencing and classical cohort research design, and carry out long-term longitudinal follow-up across generations, covering the whole life cycle and health in multi-dimension. 2. Build a disease risk prediction model for pregnant women and children with assisted reproduction. 3. Delineate the growth curve and neurobehavioral development trajectory of assisted reproductive offspring at different stages. 4. Evaluate the adolescent fertility potential and risk factors of assisted reproductive offspring.
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Health outcomes
Timeframe: 20 years