RecruitingNot Applicable

Improved Recovery of Walking in Acquired Muscle Weakness

Italy72 participantsStarted 2025-02-25

Plain-language summary

The aim of Re-Walk-Easy is to evaluate the effects of rehabilitation based on electrical stimulation on the motor performance of critically ill patients. The study will also investigate the pathophysiology of the two forms-the myopathic-predominant and the polyneuropathic-predominant variants-by examining the longitudinal progression of CIP and CIM and determining which form benefits more from electrical stimulation as a rehabilitative approach.

Who can participate

Age range

18 Years – 85 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Critical Illness Patient Inclusion Criteria: * clinical diagnosis of tetra/paraparesis of peripheral origin as disclosed by ENG/EMG examination; * be independent before the episode of critical illness Critical Illness Patient Exclusion Criteria: * history of previous comorbidity for ICU-AW; * previous known chronic polyneuropathy; * severe coagulopathy; * severe disorder of consciousness; * contraindications to Electrical Stimulation application Healthy Subjects Exclusion Criteria: * Prosthetic implants * musculoskeletal, neurological, cardiovascular and pulmonary disorders that may alter the gait

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Medical Research Council - Sum Score (MRC-SS)

Timeframe: Baseline (T0), after 15 rehabilitation sessions (each session is 60 minutes, T2), 3-month follow-up (T3)

Trial details

NCT IDNCT06786390

SponsorFondazione Don Carlo Gnocchi Onlus

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2027-12

Contact for this trial

Tiziana Lencioni

00390240308547 tlencioni@dongnocchi.it

View on ClinicalTrials.gov More Critical Illness Myopathy trials