Bone Myoregulation Reflex in Senile Osteoporosis (NCT06786195) | Clinical Trial Compass
CompletedNot Applicable
Bone Myoregulation Reflex in Senile Osteoporosis
Turkey (Türkiye)22 participantsStarted 2025-02-15
Plain-language summary
Osteoporosis is a systemic skeletal disease characterized by weakened and fragile bones. It often remains asymptomatic in its early stages but can lead to serious health problems, particularly fractures.The mechanostat theory explains that bone mass is regulated by mechanical loading. Increased activity stimulates bone formation, while decreased activity promotes bone resorption. The "bone reflex" concept further suggests that the nervous system plays a crucial role in this process by regulating both bone metabolism (osteoregulation) and muscle activity (myoregulation) in response to mechanical loading.
Who can participate
Age range
60 Years – 70 Years
Sex
MALE
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* DXA T-scores ≤-2.5 (osteoporotic) or T-scores \> -1 (no bone loss)
* Individuals who agree to participate in the study
Exclusion Criteria:
* History of musculoskeletal surgery within the past year
* Individuals with health conditions that severely affect mobility
* Vestibular disorders
* Visual impairments
* Other rheumatic, psychiatric, or severe neurological diseases
* Chronic decompensated cardiac, renal, or hepatic insufficiency
* Panic attacks
* Individuals with skin lesions on the soleus muscle
* History of fractures or prostheses in the lower extremities
* History of kidney stones
* 2+ or more edema in the lower extremities, lymphedema
* History of malignancy
* History of osteomalacia or vitamin D deficiency
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Bone myoregulation reflex latency
Timeframe: Through study completion, an average of 8 weeks.
2
Bereitschafts (Readiness) Potential
Timeframe: Through study completion, an average of 8 weeks.
Trial details
NCT IDNCT06786195
SponsorIstanbul Physical Medicine Rehabilitation Training and Research Hospital