SPECTRE is a prospective longitudinal study in order to identify whether patients with different degrees of motor recovery are distinguished by distinct brain post-stroke plasticity patterns in the acute and sub-acute phases. This study allows close longitudinal follow-up of patients with severe clinical motor impairment using functional MRI to study cerebral neuroplasticity after ischemic stroke in the acute and sub-acute phase in patients with upper limb motor impairement, taking into account prognostic criteria used in current practice.
Who can participate
Age range18 Years – 75 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Adult (age greater than or equal to 18 years) less than 75 years of age, both sexes;
* single supratentorial ischemic stroke confirmed by brain imaging
* Upper limb deficit defined by a SAFE score \<5 (SAFE Stinear protocol, prognosis of post-stroke upper limb recovery) on D3 of stroke. This corresponds to the sum of shoulder abduction and finger extension according to the MRC (Medical Research Council) scale for each of these movements out of 5.
* Absence of comprehension disorders limiting participation;
* Patient covered by french social security;
* Free, informed and written consent signed by the patient or a member of the patient's family (in the case of a patient who is able to understand the information and give consent but has motor difficulties resulting in an invalid signature).
Non-Inclusion Criteria:
* Multiple ischemic strokes or history of clinically significant stroke ;
* Posterior fossa stroke ;
* Hemorrhagic stroke;
* Patient who have undergone thrombolysis or mechanical thrombectomy;
* Extensive Fazekas grade 3 vascular leukopathy;
* Pre-existing neurodegenerative pathology;
* Patient with severe dyspnea or swallowing disorders who cannot undergo brain MRI;
* Adults under legal protection (safeguard of justice, curatorship, guardianship, family habilitation), persons deprived of liberty;
* Women declaring that they are pregnant or breast-feeding;
* Patient participating in another therapeutic or drug intervention study that may have …
What they're measuring
1
Changes in effective connectivity of Brain data (fMRI activity and CST tractography)