UnknownPhase 1

The Effect of High Single Dose of Dexamethasone in Prevention of Post-operative Acute Kidney Injury in Cardiac Surgeries Requiring Cardiopulmonary Bypass

Egypt60 participantsStarted 2025-02-01

Plain-language summary

The aim of the current study is to assess the effect of intra operative single high dose dexamethasone (1 mg/kg) in decreasing the incidence of post-operative acute kidney injury after cardiac surgeries with cardiopulmonary bypass

Who can participate

Age range30 Years – 65 Years

SexALL

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Inclusion criteria

✓. Age 30-65 years.
✓. Sex: Both sex.
✓. Patients with American Society of Anesthesiologists (ASA) score III - IV.
✓. Patients who were scheduled for any type of elective cardiac surgical procedure requiring cardiopulmonary bypass

Exclusion criteria

✕. Declining to give written informed consent.
✕. History of allergy to the medications used in the study.
✕. Emergent or planned off-pump procedure
✕. Diabetic patients.
✕. Patients with recent history of AKI, or have any renal deterioration as GFR \< 80 ml/min./1.73/m2
✕. Patients scheduled for urgent cardiac surgery.
✕. Patients scheduled for ascending aortic surgery inducing deep hypothermic total circulatory arrest.
✕. Patients on high doses of inotropes and/or vasopressors.

What they're measuring

postoperative acute kidney injury

Timeframe: 7 days

Trial details

NCT IDNCT06783634

SponsorAin Shams University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-03-25

Contact for this trial

nourhan E Abdellatif, MBBCH

+01145544757 noura.elsawy961@gmail.com

View on ClinicalTrials.gov More Acute Kidney Injury After Adult Cardiac Surgery trials