The goal of this clinical trial is to learn if berberine works to affect lipids and lipoproteins in Chinese females aged 20 to 65 years with hyperlipidaemia. The goal also includes to examine the sex-specific effect of berberine on lipids and lipoproteins. Our previous HMRF-funded randomized trial in men and prior evidence suggests berberine affects sex hormones. Given the different sex hormone profiles in men and women, the main question it aims to answer is: • Does berberine have sex-specific lipid-modifying effects? Researchers will compare berberine to a placebo (a look-alike substance that contains no drug) to see if berberine works to affect lipids and lipoproteins. Participants will: * Take a baseline questionnaire * Take berberine or a placebo every day for 12 weeks * Take follow-up visits after 8 weeks and 12 weeks for blood sample collections and tests
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Total cholesterol in mmol/L
Timeframe: 4 months for biomarker assessment, 6 months for data analysis
LDL-cholesterol in mmol/L
Timeframe: 4 months for biomarker assessment, 6 months for data analysis
Triglycerides in mmol/L
Timeframe: 4 months for biomarker assessment, 6 months for data analysis
Apolipoprotein B in mg/dL
Timeframe: 4 months for biomarker assessment, 6 months for data analysis
Lipoprotein (a) in mg/dL
Timeframe: 4 months for biomarker assessment, 6 months for data analysis