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Clinical Performance of Resin Composite Restoration After Dentin Biomodification by Grape Seed Extract in Deep Carious Lesions.

60 participantsStarted 2025-06-01

Plain-language summary

This study will evaluate the clinical and radiographic performance of resin composite restoration after utilized a grape seed extract as dentin biomodification in vital teeth with deep occlusal carious lesions (ICDAS 5-6) after selective soft dentin removal technique.

Who can participate

Age range22 Years – 42 Years

SexALL

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Inclusion criteria

✓. Adult patients (age: 22-42 years) of both genders.
✓. Good oral hygiene.
✓. Willing to sign the informed consent.
✓. Co-operative patients who accept the follow-up period.
✓. Posterior permanent caries (ICDAS 5\&6).
✓. Radiographically, caries is extending 50% of dentine with a radiopaque layer between the carious lesion and the pulp chamber.
✓. Sensible teeth according to cold pulp test.
✓. Negative response in percussion test.

Exclusion criteria

✕. Allergy to any of the restorative materials.
✕. Patients undergoing orthodontic treatment with fixed appliances.
✕. Pregnant women.
✕. Patients with debilitating systemic diseases.
✕. Patient who frequently use analgesic or any drugs that could mask the pain.
✕. Teeth with previous restorations.
✕. Spontaneous pain or prolonged pain (more than 15 s) after sensitivity test (cold test), which would indicate irreversible pulpitis.
✕. Negative sensibility tests, periapical radiolucencies and sensitivity to axial or lateral percussion.

What they're measuring

Clinical Performance (Biological properties), Revised FDI criteria. (Clinically excellent-Success rate)

Timeframe: 18 month

Trial details

NCT IDNCT06780527

SponsorCairo University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-12-01

Contact for this trial

Marwah Faker Mohammed Al-Emad (M.F.) Master's student, Master

(+2) 01116398243 marwah.faker@dentistry.cu.edu.eg

View on ClinicalTrials.gov More Deep Carious Lesions trials