UMMS Sepsis Early Prediction Score (SEPSys) and RESCUE Score Combined Clinical Trial (NCT06779617) | Clinical Trial Compass
RecruitingNot Applicable
UMMS Sepsis Early Prediction Score (SEPSys) and RESCUE Score Combined Clinical Trial
United States150,000 participantsStarted 2026-02-01
Plain-language summary
This study is designed to test two new risk scores - one designed to predict a patient's four-hour risk of developing sepsis and one designed to predict a patient's four-hour risk of deterioration (cardiac arrest, death, unplanned ICU transfer, or rapid response team call). The goal of this study is to improve provider awareness of a patient's risk of these two negative outcomes by providing them with new risk scores. The primary outcome will be the time from when the risk score becomes elevated to when vital signs such as heart rate or blood pressure are measured, suggesting an increased awareness.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Hospital Unit Inclusion Criteria:
* Units are part of a member hospital of the University of Maryland Medical System (UMMS)
* Units treat inpatient patients
* Units agree to participate in the study
General Encounter Inclusion Criteria:
* Encounter is on a participating inpatient unit
* Encounter is associated with a bedded patient in the hospital
* Encounter is associated with an adult (at least 18 years of age at time of admission)
Additional SEPSys Encounter Inclusion Criteria:
• Encounter has a SEPSys Score
Additional RESCUE Encounter Inclusion Criteria:
• Encounter has a RESCUE Score
Exclusion Criteria:
Hospital Unit Exclusion Criteria:
* Unit treats exclusively outpatients or is located in an outpatient setting
* Unit treats primarily or exclusively pediatric patients (patients under the age of 18 years old)
* Unit treats exclusively psychiatric patients
Additional SEPSys Encounter Exclusion Criteria:
* Encounter is with OB for a normal delivery and the patient has yet to give birth. This encounter can become eligible once the patient has given birth.
* Encounter is admitted with a diagnosis of sepsis
* Sepsis was already diagnosed during the encounter
This encounter will have been eligible until the patient began showing clinical signs or symptoms of sepsis or received a diagnosis of sepsis. Once they have a diagnosis or clinical signs or symptoms of sepsis, their SEPSys Score will no longer be updated. Data will continue to be collected on time of laborat…
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Time To Vital Sign Measurement
Timeframe: From time of elevation of either the Sepsis Early Prediction System (SEPSys) or RESCUE Score to measurement of vital signs, assessed continually during the hospitalization (up to 24 hours after the elevation)).