RecruitingNot Applicable

MR Elastography for Assessing Liver Fibrosis in Chronic Hepatitis B

China600 participantsStarted 2025-01-01

Plain-language summary

How to construct a non-invasive, accurate, and convenient method to evaluate the severity of liver fibrosis (LF) is an important general problem in the management of patients with chronic hepatitis B (CHB). We plan to investigate the ability of magnetic resonance elastography (MRE) to grade fibrosis in chronic hepatitis B and apply to clinical longitudinal follow-up.

Who can participate

Age range18 Years – 80 Years

SexALL

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Inclusion Criteria: * Age ≥ 18 years old * Confirmed CHB (laboratory, imaging and clinical tests) * MRE within 6 months before and after liver biopsy * Treatment-naïve * Child-Pugh Grade A (\<7 points) * Written informed consent in prospective follow-up cohort Exclusion Criteria: * Patients with liver malignant tumor * Chronic hepatitis due to other causes (such as alcoholic hepatitis) * CHB combined with hepatitis C, hepatitis D, or HIV * Patients with biliary tract diseases * Contraindications of MRE examination, MRE failure * Poor pathological effect

What they're measuring

Accuracy of the features of MRE for grading fibrosis in chronic hepatitis B.

Timeframe: 6 months

Trial details

NCT IDNCT06779058

SponsorShengjing Hospital

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2026-12-01

Contact for this trial

Yiyang Wang

+86 15291014907 15291014907@163.com

View on ClinicalTrials.gov More Chronic Hepatitis B trials