Active — Not RecruitingNot Applicable

ThRombectomy In Mild Ischemic Stroke With a Visible Intracranial veSsel Occlusion

United States5,000 participantsStarted 2018-01-01

Plain-language summary

The purpose of TRIMIS is to study how a medical procedure by the name of endovascular therapy compares to medical treatment alone in patients with mild stroke and a blood vessel occlusion in the brain

Who can participate

Age range18 Years

SexALL

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Inclusion criteria

✓. Acute ischemic stroke in an adult patient (18 years of age or older).
✓. Onset (Last Seen Normal) time to treatment time \<24 hours or unknown Last Seen Normal in whom Endovascular Therapy could be considered per local radiographic guidelines.
✓. Mild stroke defined as an NIH Stroke Scale ≤ 5 at the time of treatment decision.
✓. An acute intracranial vessel occlusion (Intracranial Internal Carotid Artery terminus (T or L clot), Middle Cerebral Artery (M1, M2, M3/beyond), Anterior Cerebral Artery (A1, A2, A3), V4, Basilar, Posterior Cerebral Artery) defined by non-invasive acute imaging (Computed Tomography, angiography (Computed Tomography Angiography) or Magnetic Resonance angiography (MRA)) that is neurologically relevant to the presenting symptoms and signs.

Exclusion criteria

✕. Stroke symptoms due to another non-ischemic acute neurological condition such as seizure with Post-ictal Todd's paralysis or focal neurological signs due to severe hypo- or hyperglycemia.
✕. Hyperdensity on Non-contrast Computed Tomography consistent with intracranial hemorrhage. Any clinical suspicion of any intracranial hemorrhage even in the absence of visible blood on baseline brain imaging.
✕. Large acute stroke \>1/3 Middle Cerebral Artery territory or Alberta Stroke Programme Early CT score (ASPECTS\<6 or established frank hypodensity relevant to the presenting acute stroke already visible on baseline CT scan.
✕. Findings on acute CT or MRI to suggest that the
✕. Patient has a severe or fatal or disabling illness that will impact decision regarding acute reperfusion therapies.
✕. Pregnancy.
✕. Clinical history, past imaging and clinical judgment suggest that the intracranial occlusion is chronic.
✕. Stroke occurred as an inpatient.

What they're measuring

Modified Rankin Scale

Timeframe: 90 Days

Trial details

NCT IDNCT06778226

SponsorUniversity of Miami

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2026-05-01

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