The purpose of this study is to determine the absorption, metabolism, and excretion of \[14C\]-BGB-16673 and to characterize and determine, where possible, the metabolites present in plasma, urine, and feces in healthy male participants following a single oral administration.
Age range
18 Years – 55 Years
Sex
MALE
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Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Total Radioactivity Recovery (fet1-t2) in Urine and Feces
Timeframe: Approximately 35 Days
Area Under the Plasma Concentration-time Curve from Time 0 Extrapolated to Infinity (AUC0-∞) of BGB-16673
Timeframe: Approximately 35 Days
Area Under the Plasma Concentration-time Curve from Time 0 Extrapolated to Infinity (AUC0-∞) for Total Radioactivity in Plasma and Whole Blood
Timeframe: Approximately 35 Days
Area Under the Plasma Concentration-time Curve from Time 0 to the Time of the Last Quantifiable Concentration (AUC0-tlast) of BGB-16673
Timeframe: Approximately 35 Days
Area Under the Plasma Concentration-time Curve from Time 0 to the Time of the Last Quantifiable Concentration (AUC0-tlast) for Total Radioactivity in Plasma and Whole Blood
Timeframe: Approximately 35 Days
Maximum Observed Plasma Concentration (Cmax) of BGB-16673
Timeframe: Approximately 35 Days
Maximum Observed Plasma Concentration (Cmax) for Total Radioactivity in Plasma and Whole Blood
Timeframe: Approximately 35 Days
Time of the Maximum Observed Plasma Concentration (Tmax) of BGB-16673
Timeframe: Approximately 35 Days
Time of the Maximum Observed Plasma Concentration (Tmax) for Total Radioactivity in Plasma and Whole Blood
Timeframe: Approximately 35 Days
Apparent Terminal Elimination Half-life (t1/2) of BGB-16673
Timeframe: Approximately 35 Days
Apparent Terminal Elimination Half-life (t1/2) for Total Radioactivity in Plasma and Whole Blood
Timeframe: Approximately 35 Days
Urinary recovery of BGB-16673 (fet1-t2)
Timeframe: Approximately 35 Days
Quantitative metabolic profiles of BGB-16673 in plasma and excreta
Timeframe: Approximately 35 Days
Identification of BGB-16673 major metabolites in plasma and excreta
Timeframe: Approximately 35 Days