RecruitingNot Applicable

Upper Airway Inflammation and Olfaction: Mechanisms of Loss and Recovery

Belgium140 participantsStarted 2023-05-22

Plain-language summary

The goal of this clinical trial is to understand the mechanisms leading to olfactory dysfunction (OD) in chronic rhinosinusitis (CRS). The main questions it aims to answer are: * Is the type 2 inflammation impacting the olfactory epithelium regeneration, leading to OD? * Does a treatment interfering with one of the major T2 inflammatory cytokines, have an impact on the mechanisms of OD in CRS? Participants will undergo olfactory testing and nasal brushing before and after 3 months of treatment.

Who can participate

Age range18 Years – 70 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * At least two of the following symptoms: nasal obstruction, rhinorrhoea, smell loss, facial pain for 12 weeks. * Endoscopic visualisation of bilateral sinonasal polyps * SSI (TDI) \< 30.75 and decreased sense of smell subjectively * Eosinophilia \> 300/μl of blood Ku/l * On a stable nasal steroid treatment for at least 4 weeks Exclusion Criteria: * Active smoking * Primary and secondary immune deficiencies * Ciliary diseases (cystic fibrosis, primary ciliary diskinesia) * History of or current nasal malignancies * \< 18 years and \> 70 years * Patients unable to express consent * Use of systemic corticosteroids for \< 4 weeks before visit 1 • Use of systemic or local antibiotics for \< 4 weeks before visit 1

What they're measuring

Genetic profile comparison after single-cell RNA sequencing

Timeframe: Through study completion, an average of 2 years

Trial details

NCT IDNCT06776042

SponsorCliniques universitaires Saint-Luc- Université Catholique de Louvain

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-09-30

Contact for this trial

Valérie Hox, MD, PhD

+3227648675 valerie.hox@saintluc.uclouvain.be