CompletedNot Applicable

Modified Diaphragmatic Plication Rectifies Dyspnea

China50 participantsStarted 2023-02-01

Plain-language summary

Traditional diaphragmatic plication (DP) surgery is employed to ameliorate respiratory function in patients with diaphragmatic paralysis, which is rather complicated. This study introduces a modified method of DP. The efficacy of modified diaphragmatic plication (MDP) in preventing, treating, and relieving dyspnea in patients with phrenic nerve resection or injury due to extensive surgical intervention or local tumor invasion will be evaluated.

Who can participate

Age range18 Years – 70 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Preoperative chest X-ray suggesting diaphragmatic eventration, for which therapeutic MDP was performed; * Mediastinal tumors encircling the phrenic nerve that could not be dissected or phrenic nerve injury occurring during intraoperative dissection, for which prophylactic MDP was performed; * Diaphragmatic eventration and dyspnea following mediastinal surgery, for which salvage MDP was performed. Exclusion Criteria: * Congenital diaphragmatic deformity or diaphragmatic weakness due to poor general nutritional status; * Morbid obesity with a BMI greater than 35 kg/m2; * Neuromuscular diseases, including amyotrophic lateral sclerosis and myasthenia gravis; * A history of upper abdominal surgery; and (5) Diaphragmatic calcification or fibrosis.

What they're measuring

Effective rates of prevention of diaphragmatic elevation

Timeframe: 1 year

Success in correcting diaphragmatic elevation

Timeframe: 1 year

Trial details

NCT IDNCT06775873

SponsorTongji University

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2023-05-01

View on ClinicalTrials.gov More Phrenic Nerve Injury trials