RecruitingNot Applicable

Associations Between Dietary Intake and Cardiometabolic and Gut Microbiota Outcomes

Singapore240 participantsStarted 2025-02-03

Plain-language summary

This cross-sectional study aims to investigate the associations between dietary intake, cardiometabolic health markers, and gut microbiota composition in Singapore adults.

Who can participate

Age range

21 Years – 80 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

. Able to give informed consent
. Adults 21-80 years old
. English-literate
. Have venous access sufficient to allow for blood sampling as per the protocol
. No drastic change of diet for the past 1 year
. If taking medication, has been consistently taking antihypertensive/cholesterol-lowering/type-2 diabetic medication for more than 5 years prior to starting the study.

Exclusion criteria

. Taking dietary supplements and fermented foods, which may impact the gut microbiota (e.g. antibiotics, prebiotics, probiotics, yogurt, kimchi) 2 months before starting the 1st study visit only.
. Taking dietary supplements or medications, which may impact sleep outcomes (e.g. Nutritional Shakes (e.g. Ensure), tryptophan, 5-hydroxytryptophan or melatonin supplementations) 1 month before starting the study.
. Taking dietary supplements which may impact the eye outcomes (e.g. Vitamin A, vitamin A-containing multivitamin) 2 months before starting the study.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Dietary intake

Timeframe: Day 7

Blood pressure

Timeframe: Day 1

Blood lipid lipoprotein profile

Timeframe: Day 1

Fasting blood glucose

Timeframe: Day 1

Endothelial Progenitor Cell Count

Timeframe: Day 1

Fecal short chain fatty acid (SCFA) concentration

Timeframe: Day 1

Trimethylamine N-oxide (TMAO)

Timeframe: Day 1

Fecal bile acids

Timeframe: Day 1

Trial details

NCT IDNCT06775132

SponsorNational University of Singapore

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2025-09-30

Contact for this trial

Yao Yueying

+65 83136733 yueying.yao@u.nus.edu

View on ClinicalTrials.gov More Cardiometabolic Risk Factors trials

Who can participate

Age range

21 Years – 80 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

. Able to give informed consent
. Adults 21-80 years old
. English-literate
. Have venous access sufficient to allow for blood sampling as per the protocol
. No drastic change of diet for the past 1 year
. If taking medication, has been consistently taking antihypertensive/cholesterol-lowering/type-2 diabetic medication for more than 5 years prior to starting the study.

Exclusion criteria

. Taking dietary supplements and fermented foods, which may impact the gut microbiota (e.g. antibiotics, prebiotics, probiotics, yogurt, kimchi) 2 months before starting the 1st study visit only.
. Taking dietary supplements or medications, which may impact sleep outcomes (e.g. Nutritional Shakes (e.g. Ensure), tryptophan, 5-hydroxytryptophan or melatonin supplementations) 1 month before starting the study.
. Taking dietary supplements which may impact the eye outcomes (e.g. Vitamin A, vitamin A-containing multivitamin) 2 months before starting the study.

What they're measuring

Dietary intake

Timeframe: Day 7

Blood pressure

Timeframe: Day 1

Blood lipid lipoprotein profile

Timeframe: Day 1

Fasting blood glucose

Timeframe: Day 1

Endothelial Progenitor Cell Count

Timeframe: Day 1

Fecal short chain fatty acid (SCFA) concentration

Timeframe: Day 1

Trimethylamine N-oxide (TMAO)

Timeframe: Day 1

Fecal bile acids

Timeframe: Day 1