RecruitingNot Applicable

Associations Between Dietary Intake and Cardiometabolic and Gut Microbiota Outcomes

Singapore240 participantsStarted 2025-02-03

Plain-language summary

This cross-sectional study aims to investigate the associations between dietary intake, cardiometabolic health markers, and gut microbiota composition in Singapore adults.

Who can participate

Age range21 Years – 80 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

✓. Able to give informed consent
✓. Adults 21-80 years old
✓. English-literate
✓. Have venous access sufficient to allow for blood sampling as per the protocol
✓. No drastic change of diet for the past 1 year
✓. If taking medication, has been consistently taking antihypertensive/cholesterol-lowering/type-2 diabetic medication for more than 5 years prior to starting the study.

Exclusion criteria

✕. Taking dietary supplements and fermented foods, which may impact the gut microbiota (e.g. antibiotics, prebiotics, probiotics, yogurt, kimchi) 2 months before starting the 1st study visit only.
✕. Taking dietary supplements or medications, which may impact sleep outcomes (e.g. Nutritional Shakes (e.g. Ensure), tryptophan, 5-hydroxytryptophan or melatonin supplementations) 1 month before starting the study.
✕. Taking dietary supplements which may impact the eye outcomes (e.g. Vitamin A, vitamin A-containing multivitamin) 2 months before starting the study.

What they're measuring

Dietary intake

Timeframe: Day 7

Blood pressure

Timeframe: Day 1

Blood lipid lipoprotein profile

Timeframe: Day 1

Fasting blood glucose

Timeframe: Day 1

Endothelial Progenitor Cell Count

Timeframe: Day 1

Fecal short chain fatty acid (SCFA) concentration

Timeframe: Day 1

Trimethylamine N-oxide (TMAO)

Timeframe: Day 1

Fecal bile acids

Timeframe: Day 1

Fecal zonulin

Timeframe: Day 1

Trial details

NCT IDNCT06775132

SponsorNational University of Singapore

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2025-09-30

Contact for this trial

Yao Yueying

+65 83136733 yueying.yao@u.nus.edu

View on ClinicalTrials.gov More Cardiometabolic Risk Factors trials

Who can participate

Age range21 Years – 80 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

✓. Able to give informed consent
✓. Adults 21-80 years old
✓. English-literate
✓. Have venous access sufficient to allow for blood sampling as per the protocol
✓. No drastic change of diet for the past 1 year
✓. If taking medication, has been consistently taking antihypertensive/cholesterol-lowering/type-2 diabetic medication for more than 5 years prior to starting the study.

Exclusion criteria

✕. Taking dietary supplements and fermented foods, which may impact the gut microbiota (e.g. antibiotics, prebiotics, probiotics, yogurt, kimchi) 2 months before starting the 1st study visit only.
✕. Taking dietary supplements or medications, which may impact sleep outcomes (e.g. Nutritional Shakes (e.g. Ensure), tryptophan, 5-hydroxytryptophan or melatonin supplementations) 1 month before starting the study.
✕. Taking dietary supplements which may impact the eye outcomes (e.g. Vitamin A, vitamin A-containing multivitamin) 2 months before starting the study.

What they're measuring

Dietary intake

Timeframe: Day 7

Blood pressure

Timeframe: Day 1

Blood lipid lipoprotein profile

Timeframe: Day 1

Fasting blood glucose

Timeframe: Day 1

Endothelial Progenitor Cell Count

Timeframe: Day 1

Fecal short chain fatty acid (SCFA) concentration

Timeframe: Day 1

Trimethylamine N-oxide (TMAO)

Timeframe: Day 1

Fecal bile acids

Timeframe: Day 1

Fecal zonulin

Timeframe: Day 1