UnknownNot Applicable

Effect of Overdose Ultrasound on Osteoarthritic Knee in Adult Albino Rat: a Histological Study

Egypt40 participantsStarted 2024-02-07

Plain-language summary

The purpose of this study is to investigate the effect of overdose ultrasound on the articular cartilage of the osteoarthritic knee in adult albino rate. The US is considered the most popular and effective treatment for osteoarthritis as it can penetrate deep tissue reaching internal structures which allow it to be effective for osteoarthritis treatment. Previous researches apply US as a treatment for different cases with different intensity and repetition, but no one has actually proven the frequency of this use or the effect of excess use on cells, so the investigators need evidence to determine the optimum therapeutic dose and frequent repetition which should determine the effect of more than one session on the joint cartilage and cells and if it has a positive or negative effect and this is the main goal in this study which is limited in all studies concerning the US.

Who can participate

Age range

7 Weeks – 8 Weeks

Sex

MALE

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Forty male Albino rats will be used for the study of knee osteoarthritis. * At 7-8 weeks of age. * 200-250 grams in weight will be obtained from the animal facility of the histology department, Faculty of Medicine, Tanta University. Exclusion Criteria: * Weight \< 200-250 \> kg. * Rats with injured thighs and/or knees. * Female rats.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Samples to estimate the knee cartilage thickness (femoral cartilage)

Timeframe: at the begginig of the experiment and at the end

Samples to detect the morphology and the histological changes in cartilage matrix

Timeframe: at the begginig of the experiment and at the end

Cellular changes

Timeframe: at the begginig of the experiment and at the end

Inflammatory changes

Timeframe: at the begginig of the experiment and at the end

Trial details

NCT IDNCT06774469

SponsorCairo University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-03-09

View on ClinicalTrials.gov More Osteoarthritis of Knee trials

Plain-language summary

Who can participate

Age range

7 Weeks – 8 Weeks

Sex

MALE

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Samples to estimate the knee cartilage thickness (femoral cartilage)

Timeframe: at the begginig of the experiment and at the end

Samples to detect the morphology and the histological changes in cartilage matrix

Timeframe: at the begginig of the experiment and at the end

Cellular changes

Timeframe: at the begginig of the experiment and at the end

Inflammatory changes

Timeframe: at the begginig of the experiment and at the end