Intravenous and inhalation combined anesthesia is a commonly used method for maintaining general anesthesia in clinical practice. This study aims to explore the interaction between ciprofol and sevoflurane. By employing response surface methodology, we constructed a three-dimensional pharmacodynamic interaction surface for various dose combinations of ciprofol and sevoflurane. This approach allows us to determine the nature of the interaction between the two drugs at any given level, thereby providing a ciprofol understanding of the dose-response relationship when ciprofol and sevoflurane are used in combination. This knowledge will serve as a theoretical basis for rational drug administration during surgery.
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Bispectral Index (BIS) value
Timeframe: Induction period of anesthesia
The score of Observer's Assessment of Alertness/Sedation Scale
Timeframe: Induction period of anesthesia
Numbers of of participants with laryngoscopy and tracheal intubation positive response
Timeframe: Induction period of anesthesia
Numbers of participants with tracheal intubation stress positive respose
Timeframe: Induction period of anesthesia
Blood plasma concentration
Timeframe: Induction period of anesthesia