CompletedPhase 4

Lidocaine-based Versus Opioid-based Induction of Anesthesia in Emergency Laparotomy

Egypt149 participantsStarted 2025-02-01

Plain-language summary

Lidocaine-based anesthesia had been recently reported as a successful regimen for induction of anesthesia in elderly population with better hemodynamic profile than opioid-based induction. The investigators hypothesize that lidocaine-based induction of anesthesia would provide superior hemodynamic profile compared to conventional opioid-based induction of anesthesia in emergency laparotomy.

Who can participate

Age range18 Years – 65 Years

SexALL

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Inclusion criteria

✓. Adult patients
✓. Both gender
✓. American Society of Anesthesiologists (ASA) class I-III undergoing emergency laparotomy.

Exclusion criteria

✕. Patient refusal
✕. Severe cardiac morbidities (impaired contractility with ejection fraction \< 45%, heart block, arrhythmias, tight valvular lesions)
✕. Baseline mean arterial pressure \<75 mmHg
✕. Patients on vasopressor infusion,
✕. Patients with high shock index (heart rate / systolic blood pressure \>1)
✕. Pregnant or lactating women,
✕. Allergy of any of the study drugs
✕. Uncontrolled hypertension

What they're measuring

Hypotension

Timeframe: immediately after induction of anesthesia until 20 minutes after induction of anesthesia

Trial details

NCT IDNCT06772727

SponsorCairo University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-10-30

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