Longitudinal Study of the GLUcagon REsponse to Hypoglycemia in Children and Adolescents With New-onset Type 1 DIAbetes

WP1 : * Inclusion criteria: * De novo type 1 diabetic patient, as per ISPAD criteria; * Symptoms of hyperglycemia: polyuria-polydipsia-amaigrin +/- Acido ketosis. * Fasting blood glucose ≥126 mg/dL AND/OR blood glucose ≥200 mg/dL at 120 minutes of an OGTT AND/OR HbA1c ≥6.5% AND/OR a patient with symptoms of hyperglycemia/hyperglycemic crisis (see 8. a. 2.) with random blood glucose ≥200 mg/dL. Presence in serum of one or more anti-islet autoantibodies (anti-insulin, anti-IA2, anti-GAD65, anti-ZnT8) * Patients aged between 2 and 30 years * Minimum weight: 17 kg (for blood samples) * Male - female patients * Free, written and oral consent. * Exclusion criteria: * Child under 2 years of age. * Taking treatments interfering with insulin secretion and sensitivity (e.g. sulfonylureas, diazoxide, somatostatin, methylxanthine derivatives, corticosteroids, biguanide, incretins). * Presence of newly diagnosed (within 1 month) celiac disease (diagnosed on pathological duodenal biopsy) at inclusion. * Autoimmune/autoinflammatory disease (other than type 1 diabetes) or active malignancy present at inclusion. * Obesity defined as a BMI with a z-score \>+3 SD. * Hepatic, renal or adrenal insufficiency. * History of bone marrow transplantation. * History of diabetes after hemolytic-uremic syndrome. * Epileptic patient * Absence of anti-islet autoantibodies. * Dysmorphia with suspicion of underlying genetic syndrome. * Participation in another study in the previous 3 months, with…