CompletedPhase 2/3

Effect of Use of Calcium Hydroxide and Metformin Intracanal Medicament After NSRCT

India120 participantsStarted 2023-08-01

Plain-language summary

Goal of this randomized clinical trial is evaluate the effect of Calcium Hydroxide and Metformin Intracanal Medicament on periapical healing after NSRCT. Population includes systemically healthy patient with radiographic evidence of apical periodontitis PAI score more then 3 will be recruited . Outcome will be assessed using periapical index scoring system at 6 and 12 months follow up period.

Who can participate

Age range18 Years – 55 Years

SexALL

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Inclusion criteria

✓. Mature permanent mandibular molar with necrotic pulp (absence of response to cold and electric pulp tester) and apical periodontitis requiring primary root canal treatment with radiographic evidence of periapical radiolucency (periapical index score ≥ 3).
✓. Age - Above 18 years
✓. Non-contributory medical history (ASA 1)
✓. Periodontally healthy tooth (probing depth \<4mm)

Exclusion criteria

✕. Patients who do not provide authorization for participation in the study
✕. History of analgesic intake in the previous 1 week, or antibiotic intake in 1 month
✕. Mandibular molar with no opposing teeth.
✕. Patients whose tooth had been previously accessed or endodontically treated.
✕. Patient on systemic MF or medication that interfere periapical healing
✕. Presence of bleeding on opening of pulp chamber.
✕. Diabetic, immunocompromised and pregnant patient.
✕. Teeth with cracks, fracture, internal and external resorption.

What they're measuring

periapical healing using the Periapical index score

Timeframe: 6 and12 months follow .

Trial details

NCT IDNCT06766201

SponsorPostgraduate Institute of Dental Sciences Rohtak

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2024-09-01

View on ClinicalTrials.gov More Apical Periodontitis trials