Mechanisms and Phenotypes of Hypertension in Patients in Chronic Hemodialysis (NCT06764277) | Clinical Trial Compass
CompletedNot Applicable
Mechanisms and Phenotypes of Hypertension in Patients in Chronic Hemodialysis
Mexico32 participantsStarted 2023-08-14
Plain-language summary
The goal of this study is to evaluate interdialytic blood pressure changes of the patients in chronic hemodialysis.
The main question to be answered is: What is the relative importance of weight gain, the renin angiotensin system, the sympathetic nervous system and inflammatory immune reactivity in the interdialytic hypertension of patients in chronic hemodialysis, The participants will have hemodynamic evaluation (cardiac output and peripheral vascular resistance) at the end of dialysis, ambulatory monitoring of blood pressure in the interdialytic period. Serum samples will be collected at the end of dialysis and before the start of the next dialysis, 2-3 days later.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Patients with more than 3 months in the chronic hemodialysis program in the INCMNSZ and assumed to remained in the program for longer than 3 months
* Stable patients with no change in medication 1 month prior to the study
* Unchanged drug therapy and dialysis prescription for \>1 month prior to the studies
* Informed consent to participate in the study
Exclusion Criteria:
* Patients unable to give informed consent or withdrawal of informed consent to the study
* Patients with active infection
* Patients with prosthesis or pacemakers
* Patients with immunosuppressive treatment of more than 10mg Prednisone daily
* Prior nephrectomy
* incomplete collection of data specified in the study protocol
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Cardiac Output
Timeframe: Each participant was studied once 1-3 hours after dialysis ended
2
Interdialytic Weight Change
Timeframe: Interdialytic weight change was studied once, by the difference between the weight at the end of dialysis and the weight 2-3 days later, before the next dialysis.
3
Systemic Vascular Resistance
Timeframe: Systemic vascular resistance was determined once in the participants 1-3 hours after dialysis