Exercise-induced Irisin in Individuals With Knee Osteoarthritis.

Inclusion Criteria: * Patients with idiopathic knee OA * Stage 1-3 knee OA according to the Kellgren-Lawrence classification * Patients aged 40-65 * Patients agreeing to participate in the study * Patients having physical and cognitive ability to participate in the exercise program Exclusion Criteria: * History of depression and/or anxiety etc. psychiatric disease * Uncontrolled hypertension, uncontrolled heart rhythm disorders, history of hospitalization for cardiovascular reasons in the last 6 months * History of symptomatic pulmonary disease * Use of medication due to dyslipidemia and/or diabetes * Presence of acute inflammation or effusion in the knee joint * Presence of central or peripheral neurological disease that will cause loss of lower extremity muscle strength, sensation, and balance * Presence of a prosthetic joint in the knee and previous lower extremity surgery * Having received a physical therapy program in the last 6 months * Patients with severe visual or hearing impairment * Patients with severe peripheral vascular disorders * Presence of severe knee joint instability, ligament and meniscal damage * Being illiterate