RecruitingNot Applicable

Lf-rTMS Attenuates Visceral Pain in Irritable Bowel Syndrome With Diarrhea

China42 participantsStarted 2024-08-01

Plain-language summary

Objectives: To identify a central hub of visceral pain in IBS-D and elucidate the mechanism by which repetitive transcranial magnetic stimulation (rTMS) confers analgesic effects. Methods: A total of 42 IBS-D patients were recruited and randomly assigned (1:1) to the sham rTMS or the rTMS group. A nested cohort of 21 IBS-D participants who completed baseline fMRI assessments prior to randomization was included. Consistent with the randomization procedure，these individuals were evenly distributed between the two groups. Both participants and outcome assessors remained blinded to treatment allocation throughout the study. All patients completed the two-week intervention and were included in the final analysis.

Who can participate

Age range18 Years – 75 Years

SexALL

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All diagnoses were made by board-certified gastroenterologists. Eligible participants met the following inclusion criteria: (1) age between 18 and 75 years; (2) fulfillment of the Rome IV diagnostic criteria for IBS-D. Exclusion criteria included: (1) presence of inflammatory or other organic gastrointestinal diseases; (2) diagnosed psychiatric disorders; (3) history of anorectal, intestinal, or abdominal surgery; (4) pregnancy or lactation; (5) presence of metallic implants or cardiac pacemakers.

What they're measuring

Visceral Sensitivity Index

Timeframe: 2 weeks of treatment

Trial details

NCT IDNCT06757491

SponsorThe First Affiliated Hospital of Soochow University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-12-25

Contact for this trial

Ruixia Weng, Dr.

15206214921 wengruixia@suda.edu.cn

View on ClinicalTrials.gov More Repetitive Transcranial Magnetic Stimulation trials