CompletedNot Applicable

Efficacy of Diosmin and Hesperidin on Early Rehabilitation After Total Knee Arthroplasty

Turkey (Türkiye)190 participantsStarted 2024-10-08

Plain-language summary

The goal of this clinical trial is to find out the efficacy of diosmin and hesperidin on postoperative early rehabilitation after primary total knee arthroplasty. The main questions it aims to answer are: Does diosmin and hesperidin combined drug decreases the lower extremity swelling, pain and increases the range of motion after primary total knee arthroplasty surgery compared to standard therapy group? Does diosmin and hesperidin combined drug decreases inflammation after total knee arthroplasty surgery. Participants will take diosmin and hesperidin in addition to standard therapy for 14 days after total knee arthroplasty surgery. Lower extremity swelling, pain and range of motion of the patients will be recorded in every visit.

Who can participate

Age range18 Years – 80 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Patients who underwent unilateral primary total knee replacement surgery * Patients who are functionally ASA 1, ASA 2 or ASA 3. Exclusion Criteria: * Patients \>80 years or \<18 years of age * Patients with liver insufficiency * Patients with allergy to diosmin or hesperidin * Patients which are not capable to communicate

What they're measuring

Lower extremity swelling

Timeframe: From enrollment to the end of the treatment at 2 weeks

Trial details

NCT IDNCT06753448

SponsorAnkara Etlik City Hospital

Sponsor typeOTHER_GOV

Study typeOBSERVATIONAL

Primary completion2025-06-10

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