Accumulating evidence demonstrates that breathing air pollutants leads to devastating increases in sickness and death worldwide over time. However, there is little data comparing the effects of different types of air pollution on health. In Canada, traffic-related air pollution and wood smoke (wildfires and wood burning for heating) are very common air pollutants. This study aims to safely complete a controlled human exposure study to test how these air pollution types acutely affect health.
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Woodsmoke (WS) and/or diesel exhaust (DE) exposure effects on inflammatory cells in the lungs.
Timeframe: Comparison of the different arms (over the span of ~5 months).
Within-individual change in lung transcriptomic biomarkers of inflammation following exposure to woodsmoke and/or diesel exhaust.
Timeframe: Through study completion, anticipated ~5 months.
Within-individual change in lung protein biomarkers of inflammation following exposure to woodsmoke and/or diesel exhaust.
Timeframe: Through study completion, anticipated ~5 months.
Within-individual change in circulating transcriptomic biomarkers of inflammation following exposure to woodsmoke and/or diesel exhaust.
Timeframe: Through study completion, anticipated ~5 months.
Within-individual change in circulating protein biomarkers of inflammation following exposure to woodsmoke and/or diesel exhaust.
Timeframe: Through study completion, anticipated ~5 months.
Within-individual change in airway resistance following exposures to woodsmoke and/or diesel exhaust.
Timeframe: Through study completion, anticipated ~5 months.