Methamphetamine Isomer Pharmacology in Humans

Inclusion Criteria: * Good mental health as determined by self-reported responses to the Psychopathology Screener * Absence of any major cardiac, neurologic, psychiatric, oncologic, endocrine, metabolic, renal, or hepatic disease as determined by self-reported responses to the Medical History Screener * English-speaking (able to provide consent and complete questionnaires) * Written Informed Consent Exclusion Criteria: * Any serious prior adverse response to sympathomimetic agents or amphetamine analogs * History of or current substance use disorder as determined by self-reported responses to the Internalizing, Externalizing, and Substance Use Disorder Screener * Pregnancy or lactation (pregnancy test, if needed) * Use of medications that may impact cognition or metabolism (e.g., mood stabilizers, sedatives) * Dependent on prohibited concomitant therapy that cannot be withheld for 48 hours prior to and during study visits.