BLOCK-study: Better Local Orthopedic Pain Control After Knee Arthroplasty

Inclusion Criteria: * ASA I-III * BMI 17-35 kg/m2 * Patient is able to give informed consent * Patient is scheduled for TKA Exclusion Criteria: * Refusal of patient * Inability to communicate due to language or neurologic barriers * Bilateral TKA or unilateral knee arthroplasty * Chronic opioid use (including partial opioid agonists) + chronic pain patients: * Use of atypical analgesics (gabapentin, pregabalin, …) * History of Sudeck atrophy * History of \>3 chronic pain consultations * Contraindications for spinal anesthesia * Patient refusal * Local infection * Aberrant coagulation (according to the latest ESRA guidelines) * Severe spinal canal stenosis * Intracranial hypertension * History of neurological injury in the affected limb * Contraindications for local anesthetics * Allergy for local anesthetics * Absolute contraindications for NSAIDs or paracetamol * Proven allergy for NSAID's (including ASA syndrome) or paracetamol * Severe renal function impairment (eGFR \<30 ml/min/1.73 m2) * Active or recent (\<6 months) history of gastric ulcera/perforations/bleeding * Crohn disease or colitis ulcerosa * Liver function impairment or severe renal function impairment (eGFR \<30 ml/min/1.73 m2) * Pregnancy or breast-feeding