Direct Warming Frozen Embryo Transfer Outcomes in Assisted Reproductive Technology (NCT06741748) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Direct Warming Frozen Embryo Transfer Outcomes in Assisted Reproductive Technology
Hong Kong, United Kingdom578 participantsStarted 2025-09-01
Plain-language summary
The goal of this clinical trial is to evaluate whether the direct warming method for frozen embryo transfers (FET) can improve live birth and pregnancy outcomes in women aged 18-45 undergoing IVF treatments. The main questions it aims to answer are:
* Does the direct warming method achieve a similar or higher clinical success rate for FET compared to the conventional multi-step method?
* Is the direct warming method more cost-effective than the conventional method?
Researchers will compare the direct warming method to the conventional multi-step method to see if the former leads to better pregnancy outcomes and reduced procedural time.
Participants will:
* Undergo either the one-step or conventional embryo thawing procedure.
* Complete standard clinical follow-ups for pregnancy, including ultrasound scans and pregnancy tests.
Who can participate
Age range
18 Years – 45 Years
Sex
FEMALE
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Plan to undergo single embryo transfer (SET) during the FET cycle.
* Age between 18 and 45 years.
* Patients with at least one high-quality blastocyst available for transfer.
* Patients who have provided informed consent to participate in the study.
Exclusion Criteria:
* Patients with repeated implantation failure (RIF) or recurrent miscarriage (RM).
* Patients with known uterine anomalies or significant uterine pathology (e.g., fibroids, polyps).
* Patients who are unwilling or unable to provide informed consent.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Clinical Pregnancy Rate
Timeframe: 6-8 weeks post embryo transfer
2
Ongoing Pregnancy Rate (OPR)
Timeframe: 12 weeks post embryo transfer
3
Live Birth Rate (LBR)
Timeframe: At delivery, approximately 9 months post embryo transfer
4
Cost-Effectiveness
Timeframe: At the end of the study, approximately 4 years.