CompletedNot Applicable

Ephedrine Versus Phenylephrine for Spinal Block - Related Hypotension in Cesarean Delivery

Poland94 participantsStarted 2024-12-16

Plain-language summary

The study is designed to compare two strategies used in the management of hypotension caused by spinal anesthesia for cesarean section: intravenous phenylephrine given as prophylactic infusion and interventional boluses of intravenous ephedrine. Phenylephrine is currently recommended for battling spinal anesthesia - related sympathectomy, due to some scientific data on possible negative effects of ephedrine on fetal wellbeing. Therefore this study will retrospectively compare both clinical and laboratory data of the newborns delivered by cesarean section where either large dose of ephedrine or continuous infusion of phenylephrine was used for management of hypotension

Who can participate

Age range18 Years

SexFEMALE

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Cesarean delivery at term under spinal anesthesia * American Society of Anesthesiologists (ASA) physical status \<3 * BMI \<40 * Preemptive phenylephrine infusion or ephedrine boluses used during surgical procedure Exclusion Criteria: * No vasoconstrictor (phenylephrine nor ephedrine) used throughout the procedure * Total dose of ephedrine less than 15mg * poor quality of anesthetic record - data required for analysis not available

What they're measuring

Umbilical blood pH

Timeframe: During delivery (from spinal injection to umbilical clamping and cutting)

Umbilical blood Base Excess (BE)

Timeframe: During delivery (from spinal injection to umbilical clamping and cutting)

Trial details

NCT IDNCT06741410

SponsorCentre of Postgraduate Medical Education

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2025-09-16

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