CompletedNot Applicable

40 Hz Transcranial Alternating Current Stimulation for Inducing Gamma Oscillations

Iran30 participantsStarted 2024-06-01

Plain-language summary

This study aims to compare the efficacy of different 40 Hz tACS protocols in entraining gamma oscillations, which are linked to various cognitive functions and play a significant role in cognitive impairments like Alzheimer's disease. Specifically, it examines the effects of 40 Hz tACS applied to frontal brain regions versus fronto-temporal regions on gamma oscillations and working memory in healthy elderly individuals.

Who can participate

Age range50 Years – 85 Years

SexALL

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Inclusion Criteria: * healthy elderly between 50-80 years of age * normal or corrected to normal eye vision * right-handed * non-smokers * at least 70 % accuracy in working memory training task Exclusion Criteria: * history of neurological or psychiatric disorders including seizures or epilepsy, * Taking CNS, blood pressure and other medications * having metal implants in the head and neck * significant cognitive decline meassured by The Montreal Cognitive Assessment (MoCA)

What they're measuring

Working Memory behavioral performance

Timeframe: During procedure (20 minutes)

electroencephalogram (EEG) oscillatory power

Timeframe: up to 2 hours after the intervention

electroencephalogram (EEG) functional connectivity

Timeframe: up to 2 hours after the intervention

Trial details

NCT IDNCT06740864

SponsorThe National Brain Mapping Laboratory (NBML)

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-02-01

View on ClinicalTrials.gov More Alzheimer Disease trials