Evolocumab in Patients With Multivessel Coronary Disease After Acute Myocardial Infarction: A Target Trial Emulation

Inclusion Criteria: * Age ≥18 years old; * Acute myocardial infarction diagnosed at hospital admission; * Multivessel coronary artery disease diagnosed at primary invasive coronary angiography; * Culprit vessel successfully revascularized; * At lease 1 non-culprit vessel with ≥50% stenosis and deferred at the opinion of the operator, and no staged revascularization within 6 months. Exclusion Criteria: * Cardiac shock, hemodynamically unstable, or severe heart failure (Killip IV) * Any cardiac surgery within 6 weeks prior to screening; * Moderate to severe renal dysfunction, defined as an estimated glomerular filtration rate (eGFR) less than 30 mL/min/1.73m\^2 at screening; * Contraindication or allergy to iodinated contrast agent; * Malignancy except non-melanoma skin cancers, cervical, or breast ductal carcinoma in situ within the last 5 years; * Female subject is pregnant or breastfeeding or planning to become pregnant or breastfeed in short term.