RecruitingNot Applicable

The Enhancement Effect of Low-Level Laser Therapy for Muscle Training with Combined NMES and BFR

Taiwan44 participantsStarted 2024-10-01

Plain-language summary

Blood flow restriction training (BFR) with neuromuscular stimulation (NMES) is employed for individuals with limited mobility and joint issues. However, this approach is highly susceptible to muscle fatigue, despite its potential beneficial effects on muscle strength. Recently, there has been growing interest in using low-level laser therapy (LLLT) to address muscle fatigue. LLLT, known for improving microcirculation and mitochondrial function, shows promise in alleviating enhanced muscle fatigue associated with combined BFR and NMES training. Despite these positive effects, there is limited knowledge about the short-term training impact of combined BFR and NMES with LLLT preconditioning. This project aims to investigate whether the photobiomodulation effects of LLLT could further enhance the training benefits of combined BFR and NMES. The study will employ an integrated analysis of decomposition surface EMG, EEG, and mechanomyogram to explore the behavior and neuromuscular mechanisms underlying the training benefits. If additional benefits are identified, LLLT pre-conditioning is recommended to enhance the use of combined BFR and NMES.

Who can participate

Age range20 Years – 40 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

✓. Healthy adults aged 20-40, without a diagnosis of cardiovascular or neuromusculoskeletal diseases.
✓. Normal vision range after visual correction.

Exclusion criteria

✕. Exclude students who have a teacher-student relationship with the principal investigator to ensure the participants\' autonomy.
✕. History of brain injury, stroke, spinal cord injury, or other neuromuscular-related conditions.
✕. Contraindications for laser therapy: pregnancy, malignant tumor tissues, bleeding areas, and photosensitive skin regions.
✕. Presence of any contraindications for blood flow restriction training, such as a history of injury or strain in the non-dominant arm\'s biceps, deep vein thrombosis or venous occlusion in the non-dominant arm, acute unstable fractures in the non-dominant arm, acute regional infections in the non-dominant arm, severe peripheral arterial occlusive disease in the non-dominant arm, complete lymphatic obstruction in the non-dominant arm, and edema due to acute pulmonary edema or congestive heart failure in the non-dominant arm.

What they're measuring

Myoton

Timeframe: before training, 1week of training, 2 weeks of training, at the end of 3 weeks training

Mechanomyogram

Timeframe: before training, 1week of training, 2 weeks of training, at the end of 3 weeks training

Multi-electrode surface EMG

Timeframe: before training, at the end of 3 weeks training

Dynamometer System

Timeframe: before training, 1week of training, 2 weeks of training, at the end of 3 weeks training

Trial details

NCT IDNCT06739148

SponsorNational Cheng-Kung University Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-07-31

Contact for this trial

Ing-Shiou Hwang, PhD

+886 62353535 ensureh@gmail.com

View on ClinicalTrials.gov More Blood Flow Restriction Therapy trials

Plain-language summary

Who can participate

Age range20 Years – 40 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

✓. Healthy adults aged 20-40, without a diagnosis of cardiovascular or neuromusculoskeletal diseases.
✓. Normal vision range after visual correction.

Exclusion criteria

✕. Exclude students who have a teacher-student relationship with the principal investigator to ensure the participants\' autonomy.
✕. History of brain injury, stroke, spinal cord injury, or other neuromuscular-related conditions.
✕. Contraindications for laser therapy: pregnancy, malignant tumor tissues, bleeding areas, and photosensitive skin regions.
✕. Presence of any contraindications for blood flow restriction training, such as a history of injury or strain in the non-dominant arm\'s biceps, deep vein thrombosis or venous occlusion in the non-dominant arm, acute unstable fractures in the non-dominant arm, acute regional infections in the non-dominant arm, severe peripheral arterial occlusive disease in the non-dominant arm, complete lymphatic obstruction in the non-dominant arm, and edema due to acute pulmonary edema or congestive heart failure in the non-dominant arm.

What they're measuring

Myoton

Timeframe: before training, 1week of training, 2 weeks of training, at the end of 3 weeks training

Mechanomyogram

Timeframe: before training, 1week of training, 2 weeks of training, at the end of 3 weeks training

Multi-electrode surface EMG

Timeframe: before training, at the end of 3 weeks training

Dynamometer System

Timeframe: before training, 1week of training, 2 weeks of training, at the end of 3 weeks training