This study aims to evaluate the effects of a 12-week aerobic and resistance exercise program in cancer patients with cachexia compared to standard care. A total of 40 participants aged 18 to 65, diagnosed with gastrointestinal cancer and cachexia, will be included in the study. Participants will be randomly assigned to the exercise group (aerobic and resistance training) or the control group (standard care), with 20 individuals in each group. Before the 12-week intervention, both the exercise and control groups will undergo evaluations. Demographic and clinical data will be recorded. The following assessments will be conducted: Body Composition: Bioelectrical impedance analysis Sarcopenia Assessment: SARC-F questionnaire Functional Exercise Capacity: 6-minute walk test Gait Parameters: 8-meter walk test Mobility and Balance: Timed Up and Go test Muscle Strength: Knee extensor and hand grip strength measured with dynamometers 30-second sit-to-stand test Additionally, participants will complete several questionnaires, including the Edmonton Symptom Assessment Scale, Karnofsky Performance Status scale, FRAIL scale, Fatigue Severity Scale, and EORTC-QLQ30. The exercise group will participate in a supervised and home-based exercise program consisting of aerobic and resistance exercises over 12 weeks. The intensity will be progressively adjusted based on the individual's perceived exertion.
Age range
18 Years – 65 Years
Sex
ALL
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Evaluation of Demographic and Clinical Information
Timeframe: At baseline and after 12 weeks of exercise training
Weight Assessment
Timeframe: At baseline and after 12 weeks of exercise training
Height Assessment
Timeframe: At baseline and after 12 weeks of exercise training
Body Mass Index Assessment Body Mass Index Assessment
Timeframe: At baseline and after 12 weeks of exercise training
Assessment of Muscle Strength
Timeframe: At baseline and after 12 weeks of exercise training
Assessment of Lower Extremity Performance
Timeframe: At baseline and after 12 weeks of exercise training
Sarcopenia Assessments
Timeframe: At baseline and after 12 weeks of exercise training
Assessment of Muscle and Fat Mass
Timeframe: At baseline and after 12 weeks of exercise training
Mobility, balance and performance assessment
Timeframe: At baseline and after 12 weeks of exercise training
Assessment of Functional Exercise Capacity
Timeframe: At baseline and after 12 weeks of exercise training
Assessment of Gait Parameters
Timeframe: At baseline and after 12 weeks of exercise training