Not Yet RecruitingNot Applicable

Ultrasound Assessment of the Thickening Fraction of the Respiratory Muscles for Predicting Weaning Outcomes

80 participantsStarted 2025-01

Plain-language summary

The accuracy of ultrasound assessment of the thickening fraction of the diaphragm, parasternal intercostal, and abdominal expiratory muscles for predicting weaning outcomes in mechanically ventilated patients. A prospective observational study

Who can participate

Age range18 Years

SexALL

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Inclusion criteria

✓. Resolution or improvement of the disease leading to MV.
✓. Adequate oxygenation, indicated by arterial oxygen partial pressure to inspired oxygen fraction (PaO2/FiO2) ≥ 200 mmHg, both with positive end-expiratory pressure (PEEP) ≤ 5 cmH2O and rapid shallow breathing index\< 105.
✓. Adequate pulmonary function, indicated by a RR\<30 breaths/min with VT ≥5 mL/kg ideal body weight (IBW) and no significant respiratory acidosis with normal serum electrolytes.
✓. Stable hemodynamics status, without or with minimal vasopressors
✓. Conscious and cooperative patient
✓. Absence of excessive tracheobronchial secretion (\<3 times suction in the past 8 hours).

Exclusion criteria

✕. Pregnancy.
✕. Presence of tracheostomy, pleural effusion, pneumothorax, pneumomediastinum, or hemothorax.
✕. Presence of rib fractures.
✕. Pre-existing cervical spinal injury, history or final diagnosis of neuromuscular disorders, and diaphragmatic paralysis or disorders
✕. Use of neuromuscular blocking agents within 48 hours.
✕. A distorted abdominal wall anatomy, or damage to the abdominal wall.
✕. Patients with localized fluid collections in the abdomen, hernias, abdominal wall hematomas, inguinal masses, femoral hernias, abdominal surgeries.
✕. BMI≥ 40

What they're measuring

determine the accuracy of the thickening fraction of the diaphragm, parasternal muscles and abdominal expiratory muscles in predicting weaning outcome.

Timeframe: 2 years

Trial details

NCT IDNCT06724302

SponsorTanta University

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2026-06

Contact for this trial

Amer Soliman

+201094963127 amer.soliman0@gmail.com

View on ClinicalTrials.gov More Weaning From Mechanical Ventilation trials