This is a long-term extension trial of RAY121 in patients with immunological diseases such as antiphospholipid syndrome (APS), bullous pemphigoid (BP), Behçet's Syndrome (BS), dermatomyositis (DM), immune-mediated necrotizing myopathy (IMNM) and immune thrombocytopenia (ITP).
Who can participate
Age range
18 Years – 85 Years
Sex
ALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
. Signed informed consent form
. Have completed 4 doses of RAY121 administrations in RAY902CT trial and shown clinical responses
. Ability to comply with the study protocol, in the investigator's judgment
. For women of childbearing potential: agreement to remain abstinent (refrain from heterosexual intercourse) or use highly effective contraceptive methods during the treatment period and 20 weeks (140 days) after the last dose of RAY121
. For men: agreement to remain abstinent (refrain from heterosexual intercourse) or use contraceptive measures, and agreement to refrain from donating sperm
Exclusion criteria
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Since this is a Phase 1b long-term extension trial where the primary goal is tracking adverse events rather than proving the treatment works, what does that mean for understanding the safety and potential benefit of RAY121 for my specific condition — whether that's APS, ITP, or one of the other diseases in this study?
2This trial is 'enrolling by invitation only' — can you explain what that means, and whether there is any pathway for someone with my diagnosis to be considered, or is this limited to people who were already in an earlier RAY121 study?
3Given that this is a long-term extension trial still in Phase 1, what would you say are the key unknowns about RAY121's safety profile at this stage, and how does that compare to the risks of standard treatments available to me right now?
4Since the trial covers several different immunological diseases together, how does being in a mixed-disease study affect what we can learn about how RAY121 might specifically work for my condition?
5What would the long-term commitment of participating in a trial like this actually look like for me in terms of visits, monitoring, and time, and how would we handle my regular care if I were enrolled?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.