CompletedNot Applicable

Impact of Bone Mineral Density on Fracture Risk Assessment in RA

Turkey (Türkiye)60 participantsStarted 2022-12-04

Plain-language summary

This study investigates whether incorporating bone mineral density (BMD) into FRAX calculations changes fracture risk assessment and influences treatment decisions in rheumatoid arthritis (RA) patients. Analyzing 60 RA patients, FRAX scores for 10-year major osteoporotic and hip fractures were calculated with and without BMD. While no significant differences were found between the two methods, discrepancies in treatment recommendations were identified, particularly for hip fractures. The findings emphasize the importance of combining BMD and FRAX for a more comprehensive fracture risk assessment and informed treatment decision-making in RA patients.

Who can participate

Age range40 Years – 90 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Diagnosis of rheumatoid arthritis (RA) based on ACR/EULAR criteria. * Age between 40-90 years. * Dual-energy X-ray absorptiometry (DXA) results obtained within the past six months. * Availability of complete clinical and demographic data for fracture risk assessment. * Patients who provide informed consent for the study. Exclusion Criteria: * Patients with secondary causes of osteoporosis (e.g., hyperparathyroidism, Cushing's syndrome). * Use of medications affecting bone metabolism (e.g., glucocorticoids \>7.5 mg/day, bisphosphonates, denosumab) within the past year. * History of metabolic bone diseases other than osteoporosis (e.g., osteomalacia, Paget's disease). * Patients with a history of malignancy, except for non-melanoma skin cancer. * Incomplete or missing data required for FRAX or DXA analysis. * Any condition or comorbidity likely to affect fracture risk assessment, as determined by the clinician.

What they're measuring

Concordance Between FRAX Scores With and Without BMD

Timeframe: 0 day

Trial details

NCT IDNCT06718985

SponsorIstanbul Physical Medicine Rehabilitation Training and Research Hospital

Sponsor typeOTHER_GOV

Study typeOBSERVATIONAL

Primary completion2023-04-04