Description of the Immune Response to Yellow Fever Vaccination (NCT06718127) | Clinical Trial Compass
RecruitingNot Applicable
Description of the Immune Response to Yellow Fever Vaccination
France38 participantsStarted 2024-09-30
Plain-language summary
Vaccine protection depends on a specific adaptive immune memory. However, a little-explored aspect of certain live vaccines may provide beneficial, non-specific protection against infections or pathogens other than the one from which the vaccine is derived. This is the concept of innate immune memory or " trained immunity", which differs from adaptive memory in its non-specificity. Innate immune memory is triggered by exposure to immunostimulants, and offers protection against unrelated pathogenic threats for several months or even years.
The project aims to carry out an exploratory study to observe, in the context of current practice, the immune response obtained after a subunit and a live attenuated vaccine
Who can participate
Age range
18 Years – 65 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Age between 18 and 65
* Referred for immunisation against yellow fever and typhoid
* Any person with indication for the following vaccinations :
* Yellow fever
* Typhoïd
* Whose vaccination schedule includes two appointments 7 days apart
* Whose state of health is compatible with a single 51 ml blood sample collection
* Have consented to participate in the Ivory2 study
* Benefiting from a Social Security plan or equivalent
Exclusion Criteria:
* Anyone with a contraindication to yellow fever and/or typhoid vaccination.
* Any person who has been vaccinated against yellow fever and/or typhoid.
* Anyone who has lived in an endemic area (≥ 1 year) and/or has a history of Typhoid.
* Anyone who is unable to attend the visit 1-month after the typhoid vaccine injection.
* Women claiming to be pregnant or breast-feeding
* Anyone unable to give informed consent for participation
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Immunological profile of PBMCs, before and after yellow fever vaccination