Not Yet RecruitingNot Applicable

Role of Interleukin 18 (IL-18) and Interleukin 18 Binding Protein (IL-18BP) in the Diagnostic Work-up of Systemic Juvenile Idiopathic Arthritis and Autoinflammatory Diseases: Possible Biomarkers in the Differential Diagnosis of Other Febrile Diseases

Italy9 participantsStarted 2027-01-01

Plain-language summary

Literature data suggest that elevated blood values of IL-18 and IL-18 Binding Protein and alterations in their ratio may be significantly correlated with various autoinflammatory diseases, such as systemic juvenile idiopathic arthritis, recurrent autoinflammatory fevers etc. In this view, the clinical implication of this observational, prospective, single-centre, non-pharmacological study will be the definition of new laboratory markers that may be useful in the early differential diagnosis of certain rare and serious paediatric diseases.

Who can participate

Age range2 Years – 18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Age between 2 years and 18 years; * Being affected by 1 of the following: Juvenile Idiopathic Arthritis; recurrent fever/ autoinflammatory disease; rheumatic disease; severe infectious diseases (sepsis, meningitis, urinary tract infection, lower respiratory tract infection); * Obtaining informed consent from parents/legal guardians of paediatric patients. Exclusion Criteria: • Patients in whom the suspicion of rheumatic disease is based on a finding of subclinical carditis or chorea.

What they're measuring

Serum levels of IL-18, and IL-18BP

Timeframe: at T0 - T1(3 months) - T2(12 months)

Trial details

NCT IDNCT06718049

SponsorIRCCS Azienda Ospedaliero-Universitaria di Bologna

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2027-12-31

Contact for this trial

Angela Miniaci, MD

00390512144811 angela.miniaci@aosp.bo.it