RecruitingNot Applicable

Effects of Endogenous Gamma Light Stimulation on Brain Oscillations in Cognitively-normal Older Adults

Taiwan52 participantsStarted 2024-12-09

Plain-language summary

This study aims to evaluate the effects of endogenous gamma non-flickering light stimulation on resting-state EEG rhythms and cognitive function in cognitively healthy older adults. Specifically, it will assess the immediate and long-term effects of this stimulation on brainwave activity and cognitive performance. The study will explore the potential of gamma light stimulation as a non-pharmacological intervention for cognitive decline in aging populations.

Who can participate

Age range

55 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * 1\. Age over 55 years old. * 2\. The Cognitive Abilities Screening Instrument (CASI) score is within normal ranges adjusted for age and education. * 3\. Participants have no history of severe neurological or psychiatric disorders (such as stroke, epilepsy, depression, migraine, etc.) that could affect cognitive function. * 4\. Participants have not used drugs that may affect cognitive function (e.g., benzodiazepines, anticholinergic medications, etc.). * 5\. Participants with normal or corrected vision (e.g., glasses or contact lenses) to normal levels. * 6\. Voluntary to sign the Informed Consent Form. Exclusion Criteria: * 1\. Participants enrolled in any cognitive enhancement study within the past two months. * 2\. Participants with a history of disease that could affect cognitive function (e.g., cancer, autoimmune diseases, etc.). * 3\. Pregnant, or planning to become pregnant.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1This trial uses something called 'endogenous gamma light stimulation' to measure changes in brain oscillations — can you explain what that actually involves and whether it's considered safe for someone my age?
2Since this trial is enrolling cognitively normal older adults, not people who already have Alzheimer's symptoms, does it make sense for me or my family member to look into it given our current situation?
3The trial is listed as Phase NA, which often means it's more of an exploratory or measurement study rather than a treatment trial — so should I understand that this is about gathering data on brain activity, not testing a therapy that could directly benefit me?
4The study is measuring gamma brain oscillations using EEG — are there any risks or discomforts involved with EEG recordings or the light stimulation itself that I should be aware of before considering participation?
5If I were to participate in this study, would it affect my ability to pursue other preventive strategies or clinical trials related to Alzheimer's risk that might be more directly focused on treatment?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Changes in gamma brain oscillations.

Timeframe: baseline (T1), post one-hour intervention (T2), post one-month intervention (T3)

Trial details

NCT IDNCT06715995

SponsorChang Gung Memorial Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-09-30

Contact for this trial

Chia-Hsiung Cheng, Ph.D.

+886-3-211800 ch.cheng@mail.cgu.edu.tw

View on ClinicalTrials.gov More EEG Brain Oscillations trials