Efficacy and Safety of Novosis Putty for Degenerative Lumbar Disease

Inclusion Criteria: * Adult aged ≥ 22 to ≤ 80 years * Subjects whose skeletal maturation are confirmed by showing the result of Risser stage 5 in Risser classification, the Plain Radiography * Subjects diagnosed with disc degeneration in the single level (L2-S1) lumbar spine along with spondylolisthesis of Meyerding grade 1 (degree of translocation: 0- \<25%) or 2 (degree of translocation: 25- \<50%) based on the results of radiological examination (CT, MRI, X-ray). * Subjects with an ODI (Oswestry Disability Index) score of ≥ 35/100 at screening * Subjects who were treated with non surgical treatment/therapy for at least 3 months, but were judged to have failed treatment by the investigator * Subjects who are willing to participate in the study, comply with treatment and procedures, and visit the hospital for all observational evaluations * Subjects who voluntarily signed the informed consent form after hearing the explanation on objectives and methods of this study Exclusion Criteria: * Subjects who have a history of medical device application (spinal instrumentation, for example, anterior disc replacement, interspinous device) to the target site or interbody fusion * Subjects who are considered that the symptoms occurring in the lumbar region are not occurred by disc degeneration * Subjects with active malignancy * Subjects with a documented history of drug abuse (e.g., psychotropic drugs including narcotic analgesics and drugs with high dependence such as alcohol) with…