CompletedPhase 3

Comparison of General Anesthesia Hemodynamics Between R and P in Patients Undergoing Laparoscopic Hepatectomy

China88 participantsStarted 2024-06-20

Plain-language summary

This study is a randomized controlled trial designed to investigate the effects of two anesthetics, remimazolam and propofol, on intraoperative hemodynamics in patients undergoing laparoscopic liver resection. The experimental group receives remimazolam, while the control group receives propofol. The primary objective is to compare the hemodynamic responses of patients in both groups during the surgical procedure, aiming to provide insights into the potential differences in cardiovascular stability and anesthetic management associated with these two drugs

Who can participate

Age range18 Years – 80 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Scheduled for LMH; * Age 18-80 years, BMI 18-28 kg/m2; * American Association of Anesthesiologists（ASA）I-III; * Child-Pugh grade A or B; * No serious heart, brain and other important organ lesions; * Informed and consent, and signed informed consent. Exclusion Criteria: * ASA IV-V or Child-Pugh C; * Left ventricular ejection fraction (EF) \<30%; * Implanted with temporary or permanent pacemakers; * Organic heart disease; * Uncontrolled hypertension, diabetes and other chronic diseases; * Prolonged use of sedative and analgesic drugs (such as opioid analgesics, benzodiazepines, antianxiety, antidepressants, antipsychotics, etc.); * Alcohol addiction; * Allergic to benzodiazepines or propofol, or to any ingredient in the studied drug; * Known history of allergy to other anesthetics; difficulty in airway and intubation during induction.

What they're measuring

Blood pressure

Timeframe: From enrollment to the end of treatment at 4 weeks

Heart rate

Timeframe: From enrollment to the end of treatment at 4 weeks

Mean arterial pressure

Timeframe: From enrollment to the end of treatment at 4 weeks

Trial details

NCT IDNCT06714669

SponsorSun Yat-sen University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2024-10-20

View on ClinicalTrials.gov More Hypotension During Surgery trials

Plain-language summary

Who can participate

Age range18 Years – 80 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.