Active — Not RecruitingNot Applicable

Effect of a Sugar Replacement on Blood Glucose Levels in Healthy Adults

United Kingdom50 participantsStarted 2025-01-17

Plain-language summary

Diabetes and cardiovascular disease account for millions of deaths per year. One of the risk factors for both conditions is high blood sugar, particularly after eating (postprandial hyperglycaemia). Lowering blood sugar levels after a meal is expected to have a positive effect on preventing metabolic and cardiovascular diseases and improving the metabolic control of those who already suffer from these conditions. The aim of this study is to investigate the effect of Oligomate® (beta-galacto-oligosaccharide) on postprandial glycaemia when used as a partial replacement of glycaemic carbohydrates in a beverage in otherwise healthy volunteers. Volunteers will be given water with either Oligomate® or glucose (control) added. Blood samples will be collected at eight time points (two before drinking the beverage and six after) to measure glucose and insulin levels.

Who can participate

Age range

18 Years – 65 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Healthy Men or Women * Body Mass Index (BMI) 18.5-29.9 kg/m\^2 * Between 18 and 65 years of age * Compliant (i.e., understands and is willing, able, and likely to comply with the experimental procedure and safety guidelines) * Able to provide informed consent * Premenopausal women must have a regular cycle or be on hormonal contraception. Exclusion Criteria: * Diabetes mellitus (all types including gestational diabetes) * HbA1c result over the study limit \[healthy range of between 4% and 5.9%\] * Endocrine disease (e.g., Cushing's syndrome) * Any food allergy or intolerance, or following Vegan diet * Medications that increase blood glucose (e.g., steroids, protease inhibitors, antipsychotics, antihypertensives, statins, diuretics, nicotinic acid, etc.) * Medications that lower glycemia (e.g., anti-hyperglycaemics, insulin, beta- blockers, etc.) * Medication affecting glucose regulation, appetite, and/or digestion/absorption of nutrients, antibiotics * Major medical or surgical event requiring hospitalization in the previous 3 months * Pregnant or lactating * Participation in another clinical/supplementation trial or actively trying to reduce body weight * Unable to comply with experimental procedures and safety guidelines * Unable to give consent * Smokers * Travel during the study period

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1This trial is studying how a sugar replacement affects blood glucose and insulin spikes after eating — given my own blood sugar patterns, does my doctor think participating in this kind of study is appropriate for me?
2Since this trial is listed as 'active, not recruiting,' it may already be full — should I ask the research team directly whether there's a waitlist or a follow-up phase I could join?
3The trial measures something called incremental area under the curve for plasma glucose, which tracks how high and how long my blood sugar rises after a meal — can my doctor explain what that means for understanding my personal risk for conditions like prediabetes or insulin resistance?
4Because this is a Phase NA study focused on healthy adults, what does my doctor think about whether findings from this trial would actually apply to my situation, especially if I already have concerns about postprandial hyperglycemia or hyperinsulinemia?
5Before considering any study like this one, would my doctor recommend I first try established dietary or lifestyle changes to manage post-meal blood sugar spikes, and how would that compare to what this trial is testing?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Difference in plasma glucose incremental area under the curve (iAUC) between study arms

Timeframe: 10 and 5 min before beverage consumption, 15, 30, 45, 60, 90, 120 min after beverage consumption

Trial details

NCT IDNCT06714552

SponsorUniversity of Aberdeen

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-04-13

View on ClinicalTrials.gov More Postprandial Hyperglycemia trials