Interleukin 8 and10 Levels Changes in Teeth With Necrotic Pulp and Apical Periodontitis (NCT06713174) | Clinical Trial Compass
CompletedNot Applicable
Interleukin 8 and10 Levels Changes in Teeth With Necrotic Pulp and Apical Periodontitis
Egypt22 participantsStarted 2024-12-15
Plain-language summary
The goal of this observational study is to evaluate changes in interleukin 8 (IL-8) and interleukin 10 (IL-10) levels in gingival crevicular fluid (GCF) and periapical fluid during root canal treatment in patients with necrotic pulp and apical periodontitis. The main question it aims to answer is:
How do IL-8 and IL-10 levels in GCF and periapical fluid change over the course of treatment?
Participants will:
Provide samples of GCF and periapical fluid at two different time points during their root canal treatment.
Undergo treatment based on standard clinical protocols for necrotic pulp and apical periodontitis.
Who can participate
Age range
18 Years – 45 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
. Adult patients aged between 18 and 45 years.
. Patients without any systemic diseases.
. Patients diagnosed with pulp necrosis and apical periodontitis of a single root with a single canal who are seeking endodontic treatment.
. Patients who have not previously received endodontic treatment or any related therapeutic procedures.
. Patients with normal periodontal health.
Exclusion criteria
. Patients who refuse to participate in the study.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
To assess changes in IL-8 and IL-10 levels in GCF and periapical fluid and evaluate if they are equivalent and can be used as markers of the inflammatory response before and during RCT.
Timeframe: The study will collect data at various time points, including baseline (pre-RCT) and during RCT.
. Patients who have been on long-term anti-inflammatory medication,received immunosuppressive chemotherapy or taken antibiotics within the last 3 weeks.
. Patients with systemic health conditions such as cardiovascular and respiratory diseases, diabetes mellitus, HIV infection, or hepatitis.
. Unrestorable teeth, pregnant women, and smokers will also be excluded from the study