The goal of this observational study is to evaluate changes in interleukin 8 (IL-8) and interleukin 10 (IL-10) levels in gingival crevicular fluid (GCF) and periapical fluid during root canal treatment in patients with necrotic pulp and apical periodontitis. The main question it aims to answer is: How do IL-8 and IL-10 levels in GCF and periapical fluid change over the course of treatment? Participants will: Provide samples of GCF and periapical fluid at two different time points during their root canal treatment. Undergo treatment based on standard clinical protocols for necrotic pulp and apical periodontitis.
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
To assess changes in IL-8 and IL-10 levels in GCF and periapical fluid and evaluate if they are equivalent and can be used as markers of the inflammatory response before and during RCT.
Timeframe: The study will collect data at various time points, including baseline (pre-RCT) and during RCT.