Effect of G-CSF on MDSC and Cancer Stem-cells Interactions in Non-small Cell Lung Cancers (CIRCUIT)

Inclusion Criteria: * Patients (male or female) aged ≥ 18 years * Histological or cytological proven lung adenocarcinoma, metastatic or locally advanced not accessible to local therapy * Receiving chemotherapy and immunotherapy as first-line treatment * Signed written informed consent (no later than the day of inclusion, and before the blood sample collection) * Patient affiliated or beneficiary to a health security system; Exclusion Criteria: * Patient with a small cell lung carcinoma * Non-metastatic disease * Actionable mutation or genomic alteration in EGFR, ALK or ROS1 * Corticosteroids \> 10 mg/j * Autoimmune disease * Active and uncontrolled HIV infection * Concomitant cancer * Pregnancy or lactating women * Psychiatric or medical conditions that prohibit the understanding and rendering of informed consent * Patient under a legal protection measure * Patient with a deprived liberty condition * Patient incapable of giving signed informed consent * Patient within the exclusion period for another clinical trial, or participating to another interventional trial within 30 days before the beginning of this project