Cardiac output (CO) is measured using Mostcare. Mean systemic filling pressure (MSFP) and vascular resistances are calculated using venous return curves constructed by measuring steady-state arterial and venous pressures and cardiac output (CO) during inspiratory hold manoeuvres at increasing plateau pressures. Measurements are performed at three incremental levels of targeted sevoflurane concentrations.
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cardiac output
Timeframe: Hemodynamic parameters are recorded after 15 min of equilibration at each sevoflurane concentration.
mean systemic filling pressure
Timeframe: Hemodynamic parameters are recorded after 15 min of equilibration at each sevoflurane concentration.
vascular resistance
Timeframe: Hemodynamic parameters are recorded after 15 min of equilibration at each sevoflurane concentration.