Exploration of the Efficacy and Mechanisms of Lymphaticovenous Anastomosis in the Treatment of Al… (NCT06706947) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Exploration of the Efficacy and Mechanisms of Lymphaticovenous Anastomosis in the Treatment of Alzheimer's Disease
China20 participantsStarted 2024-12-01
Plain-language summary
The aim of this clinical trial is to determine whether Lymphaticovenous Anastomosis can treat Alzheimer's disease，in AD patients aged 18-80.he main questions it aims to answer are:
1. Can Lymphaticovenous Anastomosis improve cognitive function, daily living ability, mood, or sleep status in patients with Alzheimer's dementia, demonstrating good therapeutic efficacy?
2. Does deep Lymphaticovenous Anastomosis lead to changes in peripheral blood biomarker levels, neuroinflammatory responses, and neuroimaging in patients with Alzheimer's dementia?
Who can participate
Age range
18 Years – 80 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
. At least two deputy chief physicians or above, diagnosed with Alzheimer's dementia according to the DSM-5 diagnostic criteria;
. Age between 18-80 years old;
. The course of the disease is at least 1 year;
. MMSE score ≤ 24 points; MoCA score \< 26
. Brain MRI shows hippocampal atrophy;
. Patients and their families agree to participate in this project for surgical treatment and sign an informed consent form.
Exclusion criteria
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial is using a surgical procedure called lymphaticovenous anastomosis to treat Alzheimer's disease, which is a very different approach from medications — can you help me understand what this surgery actually involves and why it might affect brain function?
2The trial is listed as 'not yet recruiting,' which means it hasn't started enrolling patients yet — do you know when it might open, and would it make sense for us to explore other options in the meantime rather than waiting?
3The trial is listed as Phase NA, which suggests it may be a very early exploratory study — what does that mean for how much is already known about whether this surgical approach is safe for people with Alzheimer's?
4The main outcome being measured is the Mini-Mental State Examination score — can you explain what that test actually captures, and whether a change in that score would reflect a meaningful difference in day-to-day life for someone with Alzheimer's?
5Given that this is a surgical intervention for a brain condition, what are the potential risks I should be aware of before considering whether this trial is even worth discussing further for my situation?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
. Individuals with contraindications for Lymphaticovenous Anastomosis; those allergic to anesthetics and contrast agents (indocyanine green);
. Those unable to cooperate with cranial magnetic resonance imaging and scale testing;
. Patients simultaneously suffering from schizophrenia, depression, bipolar disorder;
. Patients with severe somatic diseases (such as cardiovascular, liver, kidney, gastrointestinal, etc.), infectious diseases, and immune system disorders;
. Individuals with serious neurological diseases (such as epilepsy, cerebrovascular diseases, etc.), other types of dementia, mental retardation;