Can Computational Measures of Task Performance Predict Psychiatric Symptoms and Changes in Sympto… (NCT06705179) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Can Computational Measures of Task Performance Predict Psychiatric Symptoms and Changes in Symptom Severity Across Time
United States1,100 participantsStarted 2025-01-01
Plain-language summary
This study investigates the computational mechanisms associated with psychiatric disease dimensions. The study will characterize the relationship between computational parameter estimates of task performance and psychiatric symptoms and diagnoses with a longitudinal approach over a 12 month interval. Participants will be healthy participants recruited through Prolific an on-line crowdsourcing service, and psychiatric patients and healthy participants recruited via UCLA Psychiatry Clinics and UCLA's STAND Program
Who can participate
Age range
18 Years – 65 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria (healthy control participants):
* Age range of 18 to 65.
* Not currently having a psychiatric diagnosis determined after psychiatric evaluation by Drs. Tadayon-Nejad and Wei (both are board certified psychiatrists).
* Ability to understand and perform experimental tasks, i.e. basic ability to communicate and comprehend tasks.
* Ability to give informed consent.
Exclusion criteria (healthy control participants):
• Prior history and or current diagnosis of neurological disease.
Inclusion criteria (patients):
* Age range of 18 to 65.
* Psychiatric diagnosis of any type of depressive disorders, any type of anxiety disorders or obsessive-compulsive disorder.
* Primary or comorbid bipolar disorders are allowed but only if not in the acute manic phase.
* Comorbidity with autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD) are allowed.
* Ability to understand and perform experimental tasks, i.e. basic ability to communicate and comprehend tasks.
* Ability to give informed consent.
Exclusion criteria (patients):
* Prior history and or current diagnosis of neurological disease.
* History or current diagnosis of psychotic disorders.
* Currently active substance use disorder.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.